| Pittsburgh Panthers vs. Coker College | 11/08/2009 4:00PM | Petersen Events Center Pittsburgh, PA |  |
| Pittsburgh Panthers vs. Wofford Terriers | 11/13/2009 7:00PM | Petersen Events Center Pittsburgh, PA |  |
| Pittsburgh Panthers vs. Binghampton Bearcats | 11/17/2009 5:30PM | Petersen Events Center Pittsburgh, PA |  |
| Pittsburgh Panthers vs. Eastern Kentucky Colonels | 11/19/2009 7:00PM | Petersen Events Center Pittsburgh, PA |  |
| Pittsburgh Panthers vs. Youngstown State Penguins | 11/28/2009 12:00PM | Petersen Events Center Pittsburgh, PA |  |
| Pittsburgh Panthers vs. Duquesne Dukes | 12/02/2009 7:00PM | Mellon Arena Pittsburgh, PA |  |
| Pittsburgh Panthers vs. New Hampshire Wildcats | 12/04/2009 7:00PM | Petersen Events Center Pittsburgh, PA |  |
| Pittsburgh Panthers vs. Kent State Golden Flashes | 12/12/2009 12:00PM | Petersen Events Center Pittsburgh, PA |  |
| Pittsburgh Panthers vs. Mount St. Marys Mountaineers | 12/19/2009 TBA | Petersen Events Center Pittsburgh, PA |  |
| Pittsburgh Panthers vs. Ohio Bobcats | 12/22/2009 7:00PM | Petersen Events Center Pittsburgh, PA |  |
| Pittsburgh Panthers vs. Depaul Blue Demons | 12/28/2009 7:00PM | Petersen Events Center Pittsburgh, PA |  |
| Syracuse Orange vs. Pittsburgh Panthers | 01/02/2010 12:00PM | Carrier Dome Syracuse, NY |  |
| Cincinnati Bearcats vs. Pittsburgh Panthers | 01/04/2010 7:00PM | Fifth Third Arena Cincinnati, OH |  |
| UConn Huskies vs. Pittsburgh Panthers | 01/13/2010 7:00PM | XL Center - (Formerly Hartford Civic Center) Hartford, CT |  |
| Pittsburgh Panthers vs. Louisville Cardinals | 01/16/2010 12:00PM | Petersen Events Center Pittsburgh, PA |  |
| Pittsburgh Panthers vs. Georgetown Hoyas | 01/20/2010 7:00PM | Petersen Events Center Pittsburgh, PA |  |
| Seton Hall Pirates vs. Pittsburgh Panthers | 01/24/2010 TBA | Prudential Center Newark, NJ |  |
| Pittsburgh Panthers vs. St. Johns Red Storm | 01/28/2010 7:00PM | Petersen Events Center Pittsburgh, PA |  |
| South Florida Bulls vs. Pittsburgh Panthers | 01/31/2010 TBA | USF Sundome Tampa, FL |  |
| West Virginia Mountaineers vs. Pittsburgh Panthers | 02/03/2010 TBA | West Virginia University Coliseum Morgantown, WV |  |
| Pittsburgh Panthers vs. Seton Hall Pirates | 02/06/2010 6:00PM | Petersen Events Center Pittsburgh, PA |  |
| Pittsburgh Panthers vs. Robert Morris Colonials | 02/08/2010 8:00PM | Petersen Events Center Pittsburgh, PA |  |
| Pittsburgh Panthers vs. West Virginia Mountaineers | 02/12/2010 9:00PM | Petersen Events Center Pittsburgh, PA |  |
| Marquette Golden Eagles vs. Pittsburgh Panthers | 02/18/2010 8:00PM | Bradley Center Milwaukee, WI |  |
| Pittsburgh Panthers vs. Villanova Wildcats | 02/21/2010 12:00PM | Petersen Events Center Pittsburgh, PA |  |
| Notre Dame Fighting Irish vs. Pittsburgh Panthers | 02/24/2010 7:00PM | Joyce Center Notre Dame, IN |  |
| St. Johns Red Storm vs. Pittsburgh Panthers | 02/27/2010 12:00PM | Madison Square Garden New York, NY |  |
| Pittsburgh Panthers vs. Providence Friars | 03/04/2010 9:00PM | Petersen Events Center Pittsburgh, PA |  |
| Pittsburgh Panthers vs. Rutgers Scarlet Knights | 03/06/2010 4:30PM | Petersen Events Center Pittsburgh, PA |  |